Target-triggered deprotonation of 6-hydroxyindole-based BODIPY: specially switch on NIR fluorescence upon selectively binding to Zn2+.
نویسندگان
چکیده
Based on 6-hydroxyindole BODIPY with a Schiff-base structure, NIR fluorescence with impressively high selectivity is triggered by deprotonation of the phenol group upon binding with Zn(2+) due to the chelation-enhanced fluorescence effect, thus realizing a promising application in bioimaging of Zn(2+).
منابع مشابه
m-Benziporphodimethene: a new porphyrin analogue fluorescence zinc(II) sensor.
m-Benziporphodimethene is presented here as a long-wavelength Zn2+ specific chemosensor; this sensor shows fluorescence switch-on upon Zn2+ binding with no apparent background fluorescence.
متن کاملFluorescence Resonance Energy Transfer in Quantum Dot-Protein Kinase Assemblies
In search of viable strategies to identify selective inhibitors of protein kinases, we have designed a binding assay to probe the interactions of human phosphoinositide-dependent protein kinase-1 (PDK1) with potential ligands. Our protocol is based on fluorescence resonance energy transfer (FRET) between semiconductor quantum dots (QDs) and organic dyes. Specifically, we have expressed and puri...
متن کاملAn efficient sensor for Zn2+ and Cu2+ based on different binding modes.
An efficient sensor for Zn(2+) and Cu(2+) was designed based on different binding modes. The sensor displays ratiometric signals for Zn(2+), due to the Zn(2+)-triggered amide tautomerization; while dual-mode selective behaviors for Cu(2+) result from the deprotonation of the amide tautomer.
متن کاملSynthesis and Characterization of Far-Red/NIR-Fluorescent BODIPY Dyes, Solid-State Fluorescence, and Application as Fluorescent Tags Attached to Carbon Nano-onions.
A series of π-extended distyryl-substituted boron dipyrromethene (BODIPY) derivatives with intense far-red/near-infrared (NIR) fluorescence was synthesized and characterized, with a view to enhance the dye's performance for fluorescence labeling. An enhanced brightness was achieved by the introduction of two methyl substituents in the meso positions on the phenyl group of the BODIPY molecule; t...
متن کاملRatiometric sensing of fluoride and acetate anions based on a BODIPY-azaindole platform and its application to living cell imaging.
A new BODIPY-azaindole based fluorescent sensor 1 was designed and synthesized as a new colorimetric and ratiometric fluorescent chemosensor for fluoride. The binding and sensing abilities of sensor 1 towards various anions were studied by absorption, emission and (1)H NMR titration spectroscopies. The spectral responses of 1 to fluoride in acetonitrile-water were studied: an approximately 69 n...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Chemical communications
دوره 48 79 شماره
صفحات -
تاریخ انتشار 2012